作者
Adam H Dyer, Cyrus Vahdatpour, Albert Sanfeliu, Daniela Tropea
发表日期
2016/6/14
来源
Neuroscience
卷号
325
页码范围
89-99
出版商
Pergamon
简介
Insulin-Like Growth Factor 1 (IGF-1) is a phylogenetically ancient neurotrophic hormone with crucial roles to play in CNS development and maturation. Recently, IGF-1 has been shown to have potent effects on cellular neuroplasticity. Neuroplasticty refers to the adaptive changes made by the CNS in the face of changing functional demands and is crucial in processes such as learning and memory. IGF-1, signaling through its glycoprotein receptor (IGF-1R), and canonical signaling pathways such as the PI3K-Akt and Ras-Raf-MAP pathways, has potent effects on cellular neuroplasticity in the CNS. In the present review, the role of IGF-1 in brain development is reviewed, followed by a detailed discussion of the role played by IGF in cellular neuroplasticity in the CNS. Findings from models of perturbed and reparative plasticity detailing the role played by IGF-1 are discussed, followed by the electrophysiological …
学术搜索中的文章
AH Dyer, C Vahdatpour, A Sanfeliu, D Tropea - Neuroscience, 2016