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Although self-driving vehicles (SDVs) bring with them the promise of improved traffic safety, they cannot eliminate all crashes. Little is known about whether people respond crashes involving SDVs and human drivers differently and why. Across five vignette-based experiments in two studies (total N = 1267), for the first time, we witnessed that participants had a tendency to perceive traffic crashes involving SDVs to be more severe than those involving conventionally human-driven vehicles (HDVs) regardless of their severity (injury or fatality) or cause (SDVs/HDVs or others). Furthermore, we found that this biased response could be a result of people’s reliance on the affect heuristic. More specifically, higher prior negative affect tagged with an SDV (vs. an HDV) intensifies people’s negative affect evoked by crashes involving the SDV (vs. those involving the HDV), which subsequently results in higher perceived …