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Secretory immunoglobulin A (sIgA) has been proposed as a biomarker of stress-related psychopathology (PP), although it remains poorly studied in youth. The present study investigated sIgA acute psychosocial stress (APS) reactivity in children and adolescent and possible s-IgA alterations associated with childhood maltreatment (CM) and PP.

93 youth (7-17 years) were recruited in the EPI young stress project. To explore sIgA variability, participants gave five saliva samples during Trier Social Stress Test for Children (TSST-C). CM was evaluated following TASSCV criteria, PP via K-SDADS-PL and pubertal development by Tanner stage.

We observed sIgA fluctuations indicating the validity of TSST-C to stimulate sIgA secretion (F=4.061,p=.004). Although sIgA trajectories followed a reactivity and recovery pattern in adolescents (F=2.552,p=.042) these responses were blunted in children …