作者
Nina Singh, Jose M Aguado, Hugo Bonatti, Graeme Forrest, Krishan L Gupta, Nasia Safdar, George T John, Kenneth J Pursell, Patricia Muñoz, Robin Patel, Jesus Fortun, Pilar Martin-Davila, Bruno Philippe, François Philit, Alexis Tabah, Nicolas Terzi, Valérie Chatelet, Shimon Kusne, Nina Clark, Emily Blumberg, Marino Blanes Julia, Abhi Humar, Sally Houston, Cornelia Lass-Flörl, Leonard Johnson, Erik R Dubberke, Michelle A Barron, Olivier Lortholary
发表日期
2009/9/1
期刊
The Journal of infectious diseases
卷号
200
期号
6
页码范围
1002-1011
出版商
The University of Chicago Press
简介
BackgroundClinical characteristics, risks, and outcomes in solid organ transplant (SOT) recipients with zygomycosis in the era of modern immunosuppressive and newer antifungal agent use have not been defined
MethodsIn a matched case-controlled study, SOT recipients with zygomycosis were prospectively studied. The primary outcome measure was success (complete or partial response) at 90 days
ResultsRenal failure (odds ratio [OR], 3.17; P=.010), diabetes mellitus (OR, 8.11; P<.001), and prior voriconazole and/or caspofungin use (OR, 4.41; P=.033) were associated with a higher risk of zygomycosis, whereas tacrolimus (OR, 0.23; P=.002) was associated with a lower risk of zygomycosis. Liver transplant recipients were more likely to have disseminated disease (OR, 5.48; P=.021) and developed zygomycosis earlier after transplantation than did other SOT recipients (median …
引用总数
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N Singh, JM Aguado, H Bonatti, G Forrest, KL Gupta… - The Journal of infectious diseases, 2009