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Objective:

To identify novel and confirm previously reported metabolites associated with SBP, DBP, and hypertension in a biracial sample of Bogalusa Heart Study (BHS) participants.

Methods:

We employed untargeted, ultra-high performance liquid chromatography tandem mass spectroscopy metabolomics profiling among 1249 BHS participants (427 African-Americans and 822 whites) with BP and covariable data collected during the 2013 to 2016 visit cycle. A total of 1202 metabolites were tested for associations with continuous and binary BP phenotypes using multiple linear and logistic regression models, respectively, in overall and race-stratified analyses.

Results:

A total of 24 novel metabolites robustly associated with BP, achieving Bonferroni-corrected P less than 4.16× 10− 5 in the overall analysis and consistent effect sizes across race groups. The identified metabolites included three amino acid and …