作者
Paola Maccioni, Salvatore Serra, Giovanni Vacca, Alessandro Orrù, Daniela Pes, Roberta Agabio, Giovanni Addolorato, Mauro AM Carai, Gian Luigi Gessa, Giancarlo Colombo
发表日期
2005/7/1
期刊
Alcohol
卷号
36
期号
3
页码范围
161-168
出版商
Elsevier
简介
Recent studies have demonstrated that treatment with the γ-aminobutyric acid (GABAB) receptor agonist, baclofen, reduces alcohol intake in selectively bred Sardinian alcohol-preferring rats tested under the homecage two-bottle “alcohol versus water” choice regimen. This study was designed to investigate whether baclofen also reduces alcohol-reinforcing effects in Sardinian alcohol-preferring rats. To this aim, sP rats were trained to lever press for oral alcohol (15%, vol/vol) or sucrose (0.3%, wt/vol; included as alternative reinforcer to evaluate the specificity of baclofen effect on alcohol reinforcement) under a fixed ratio schedule of 4. Once steady levels of alcohol or sucrose self-administration behavior were established, the effects of acutely administered baclofen (0, 1.7, and 3mg/kg, intraperitoneal [ip]) and naloxone (0, 1, and 3mg/kg, ip; included as reference compound) on alcohol- or sucrose-reinforced …
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