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The similarities between the pharmacological effects of the γaminobutyric acid receptor agonist, baclofen, and the alcoholsubstituting agent, γhydroxybutyric acid, led us to investigate whether baclofen was capable of reducing (a) ethanol withdrawal syndrome in ethanoldependent rats and (b) voluntary ethanol intake in ethanolpreferring rats.

In experiment 1, Wistar rats were rendered physically dependent on ethanol by the repeated administration of intoxicating doses of ethanol for 6 consecutive days. Baclofen was acutely administered intraperitoneally at doses of 10, 20, and 40 mg/kg. In experiment 2, baclofen (0, 2.5, 5, and 10 mg/kg, intraperitoneally) was administered once a day for 14 consecutive days to ethanolpreferring sP rats that had continuous access to ethanol (10%, v/v) and water under the twobottle free choice regimen.

In experiment 1, baclofen dose …