作者
Caitlin G Howe, Bianca Cox, Ruby Fore, James Jungius, Tuomas Kvist, Samantha Lent, Harriet E Miles, Lucas A Salas, Sheryl Rifas-Shiman, Anne P Starling, Paul Yousefi, Christine Ladd-Acosta, Andrea Baccarelli, Elisabeth B Binder, Vaia Lida Chatzi, Darina Czamara, Dana Dabelea, Dawn L DeMeo, Akram Ghantous, Zdenko Herceg, Eero Kajantie, Jari MT Lahti, Debbie A Lawlor, Augusto Litonjua, Tim S Nawrot, Ellen A Nohr, Emily Oken, Costanza Pizzi, Michelle Plusquin, Katri Räikkönen, Caroline L Relton, Gemma C Sharp, Thorkild IA Sørensen, Jordi Sunyer, Martine Vrijheid, Weiming Zhang, Marie-France Hivert, Carrie V Breton
发表日期
2020/1/1
期刊
Diabetes care
卷号
43
期号
1
页码范围
98-105
出版商
American Diabetes Association
简介
OBJECTIVE
Maternal gestational diabetes mellitus (GDM) has been associated with adverse outcomes in the offspring. Growing evidence suggests that the epigenome may play a role, but most previous studies have been small and adjusted for few covariates. The current study meta-analyzed the association between maternal GDM and cord blood DNA methylation in the Pregnancy and Childhood Epigenetics (PACE) consortium.
RESEARCH DESIGN AND METHODS
Seven pregnancy cohorts (3,677 mother-newborn pairs [317 with GDM]) contributed results from epigenome-wide association studies, using DNA methylation data acquired by the Infinium HumanMethylation450 BeadChip array. Associations between GDM and DNA methylation were examined using robust linear regression, with adjustment for potential confounders. Fixed-effects meta-analyses were performed …
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CG Howe, B Cox, R Fore, J Jungius, T Kvist, S Lent… - Diabetes care, 2020
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