作者
Florianne OL Vehmeijer, Leanne K Küpers, Gemma C Sharp, Lucas A Salas, Samantha Lent, Dereje D Jima, Gwen Tindula, Sarah Reese, Cancan Qi, Olena Gruzieva, Christian Page, Faisal I Rezwan, Philip E Melton, Ellen Nohr, Geòrgia Escaramís, Peter Rzehak, Anni Heiskala, Tong Gong, Samuli T Tuominen, Lu Gao, Jason P Ross, Anne P Starling, John W Holloway, Paul Yousefi, Gunn Marit Aasvang, Lawrence J Beilin, Anna Bergström, Elisabeth Binder, Leda Chatzi, Eva Corpeleijn, Darina Czamara, Brenda Eskenazi, Susan Ewart, Natalia Ferre, Veit Grote, Dariusz Gruszfeld, Siri E Håberg, Cathrine Hoyo, Karen Huen, Robert Karlsson, Inger Kull, Jean-Paul Langhendries, Johanna Lepeule, Maria C Magnus, Rachel L Maguire, Peter L Molloy, Claire Monnereau, Trevor A Mori, Emily Oken, Katri Räikkönen, Sheryl Rifas-Shiman, Carlos Ruiz-Arenas, Sylvain Sebert, Vilhelmina Ullemar, Elvira Verduci, Judith M Vonk, Cheng-jian Xu, Ivana V Yang, Hongmei Zhang, Weiming Zhang, Wilfried Karmaus, Dana Dabelea, Beverly S Muhlhausler, Carrie V Breton, Jari Lahti, Catarina Almqvist, Marjo-Riitta Jarvelin, Berthold Koletzko, Martine Vrijheid, Thorkild IA Sørensen, Rae-Chi Huang, Syed Hasan Arshad, Wenche Nystad, Erik Melén, Gerard H Koppelman, Stephanie J London, Nina Holland, Mariona Bustamante, Susan K Murphy, Marie-France Hivert, Andrea Baccarelli, Caroline L Relton, Harold Snieder, Vincent WV Jaddoe, Janine F Felix
发表日期
2020/12
期刊
Genome medicine
卷号
12
页码范围
1-15
出版商
BioMed Central
简介
Background
DNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely unknown. More insight into this relationship at younger ages may have implications for future prevention of obesity and its related traits.
Methods
We examined whether DNA methylation in cord blood and whole blood in childhood and adolescence was associated with BMI in the age range from 2 to 18 years using both cross-sectional and longitudinal models. We performed meta-analyses of epigenome-wide association studies including up to 4133 children from 23 studies. We examined the overlap of findings reported in previous studies in children and adults with those in our analyses and calculated enrichment …
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FOL Vehmeijer, LK Küpers, GC Sharp, LA Salas… - Genome medicine, 2020