作者
Erica B Baller, Elizabeth M Sweeney, Matthew Cieslak, Timothy Robert-Fitzgerald, Sydney C Covitz, Melissa L Martin, Matthew K Schindler, Amit Bar-Or, Ameena Elahi, Bart S Larsen, Abigail R Manning, Clyde E Markowitz, Christopher M Perrone, Victoria Rautman, Madeleine M Seitz, John A Detre, Michael D Fox, Russell T Shinohara, Theodore D Satterthwaite
发表日期
2024/6/15
期刊
Biological psychiatry
卷号
95
期号
12
页码范围
1072-1080
出版商
Elsevier
简介
Background
Multiple sclerosis (MS) is an immune-mediated neurological disorder, and up to 50% of patients experience depression. We investigated how white matter network disruption is related to depression in MS.
Methods
Using electronic health records, 380 participants with MS were identified. Depressed individuals (MS+Depression group; n = 232) included persons who had an ICD-10 depression diagnosis, had a prescription for antidepressant medication, or screened positive via Patient Health Questionnaire (PHQ)-2 or PHQ-9. Age- and sex-matched nondepressed individuals with MS (MS−Depression group; n = 148) included persons who had no prior depression diagnosis, had no psychiatric medication prescriptions, and were asymptomatic on PHQ-2 or PHQ-9. Research-quality 3T structural magnetic resonance imaging was obtained as part of routine care. We first evaluated whether lesions were …
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EB Baller, EM Sweeney, M Cieslak, T Robert-Fitzgerald… - Biological psychiatry, 2024