作者
Sandra Thiel, Annette Langer-Gould, Milena Rockhoff, Aiden Haghikia, Annette Queisser-Wahrendorf, Ralf Gold, Kerstin Hellwig
发表日期
2016/5
期刊
Multiple Sclerosis Journal
卷号
22
期号
6
页码范围
801-809
出版商
SAGE Publications
简介
Background
Available data suggest that pregnancy exposure to interferon-beta might result in lower mean birth weight and preterm birth.
Objective
To determine the effect of interferon-beta exposure during pregnancy on pregnancy outcomes in multiple sclerosis patients.
Methods
We compared the pregnancy outcomes of women exposed to interferon-beta with pregnancies unexposed to disease-modifying therapies. Women were enrolled into the German Multiple Sclerosis and Pregnancy Registry. A standardized questionnaire was administered during pregnancy and postpartum. Detailed information on course of multiple sclerosis and pregnancy, concomitant medications, delivery, and outcome of pregnancy was obtained.
Results
We collected data on 251 pregnancies exposed to interferon-beta and 194 unexposed to disease-modifying therapies. In all, 246 (98.01%) women discontinued interferon-beta treatment …
学术搜索中的文章
S Thiel, A Langer-Gould, M Rockhoff, A Haghikia… - Multiple Sclerosis Journal, 2016