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Small and medium-sized enterprises (SMEs) invariably leverage a country’s economy. In this context, information and communication technology (ICT) improvements render cloud computing (CC) both an effective and cost-efficient platform for SMEs. Statistically, multiple factors influence SMEs in their adopting CC. In the subtext of a technology, environment and organization (TEO) framework, the purposefulness of this empirical study has been to identify the most prominent factors in the CC adoption, by SMEs in Pakistan. Data were collected through convenient and quota sampling methods from 103 SMEs. Both multiple regression and confirmatory factor analysis (CFA) were deployed to test the measurement model. The results show that CC adoption by SMEs is positively affected by six cogent factors, namely relative advantage, CC compatibility, managerial support, firm size, competitive pressures and …