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The increasing demand for portable computing has elevated power consumption to be one of the most critical design parameters. A high-level synthesis system, HYPER-LP, is presented for minimizing power consumption in application specific datapath intensive CMOS circuits using a variety of architectural and computational transformations. The synthesis environment consists of high-level estimation of power consumption, a library of transformation primitives, and heuristic/probabilistic optimization search mechanisms for fast and efficient scanning of the design space. Examples with varying degree of computational complexity and structures are optimized and synthesized using the HYPER-LP system. The results indicate that more than an order of magnitude reduction in power can be achieved over current-day design methodologies while maintaining the system throughput; in some cases this can be …