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In this paper, we present a discussion of the challenges for research on the topic of vehicle miles traveled. We then summarize and critique evidence from the US on the association between 14 distinct factors and vehicle miles traveled. Our results quantify how much vehicle miles traveled can be expected to change in response to changes in policy or land use factors, including residential density and land use mix, as well as specific transport policies and programs such as transit improvements, road pricing, and programs aimed at changing people’s travel choices. Overall, though individual studies differ as to exact effect sizes, it is clear that local-level policymakers can take actions that are likely to affect vehicle miles traveled. However, we highlight gaps in the knowledge base at a time when decision makers at the local level are being increasingly called upon to take action to reduce vehicle miles traveled …