作者
David J Sugarbaker, Raja M Flores, Michael T Jaklitsch, William G Richards, Gary M Strauss, Joseph M Corson, Malcolm M DeCamp Jr, Scott J Swanson, Raphael Bueno, Jeanne M Lukanich, Elizabeth Healey Baldini, Steven J Mentzer
发表日期
1999/1/1
期刊
The Journal of thoracic and cardiovascular surgery
卷号
117
期号
1
页码范围
54-65
出版商
Mosby
简介
Objectives
Our aim was to identify prognostic variables for long-term postoperative survival in trimodality management of malignant pleural mesothelioma.
Methods
From 1980 to 1997, 183 patients underwent extrapleural pneumonectomy followed by adjuvant chemotherapy and radiotherapy.
Results
Forty-three women and 140 men (age range 31-76 years) had a median follow-up of 13 months. The perioperative mortality rate was 3.8% (7 deaths) and the morbidity, 50%. Survival in the 176 remaining patients was 38% at 2 years and 15% at 5 years (median 19 months). Univariate analysis identified 3 prognostic variables associated with improved survival: epithelial cell type (52% 2-year survival, 21% 5-year survival, 26-month median survival; P = .0001), negative resection margins (44% at 2 years, 25% at 5 years, median 23 months; P = .02), and extrapleural nodes without metastases (42% at 2 years, 17% at 5 …
引用总数
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DJ Sugarbaker, RM Flores, MT Jaklitsch, WG Richards… - The Journal of thoracic and cardiovascular surgery, 1999