作者
David J Sugarbaker, Jose P Garcia, William G Richards, David H Harpole Jr, Elizabeth Healy-Baldini, Malcolm M DeCamp Jr, Steven J Mentzer, Michael J Liptay, Gary M Strauss, Scott J Swanson
发表日期
1996/9/1
期刊
Annals of surgery
卷号
224
期号
3
页码范围
288-296
出版商
LWW
简介
Objective
The authors examine the feasibility and efficacy of trimodality therapy in the treatment of malignant pleural mesothelioma and identify prognostic factors.
Background
Mesothelioma is a rare, uniformly fatal disease that has increased in incidence in recent decades. Single and bimodality therapies do not improve survival.
Methods
From 1980 to 1995, 120 patients underwent treatment for pathologically confirmed malignant mesothelioma at Brigham and Women's Hospital and Dana-Farber Cancer Institute (Boston, MA). Initial patient evaluation was performed by a multimodality team. Patients meeting selection criteria and with resectable disease identified by computed tomography scan or magnetic resonance imaging underwent extrapleural pneumonectomy followed by combination chemotherapy and radiotherapy.
Results
The cohort included 27 women and 93 men with a mean age of 56 years. Operative …
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