作者
Ana B Abecasis, Annemarie MJ Wensing, Dimitris Paraskevis, Jurgen Vercauteren, Kristof Theys, David AMC Van de Vijver, Jan Albert, Birgitta Asjö, Claudia Balotta, Danail Beshkov, Ricardo J Camacho, Bonaventura Clotet, Cillian De Gascun, Algis Griskevicius, Zehava Grossman, Osamah Hamouda, Andrzej Horban, Tatjana Kolupajeva, Klaus Korn, Leon G Kostrikis, Claudia Kücherer, Kirsi Liitsola, Marek Linka, Claus Nielsen, Dan Otelea, Roger Paredes, Mario Poljak, Elisabeth Puchhammer-Stöckl, Jean-Claude Schmit, Anders Sönnerborg, Danika Stanekova, Maja Stanojevic, Daniel Struck, Charles AB Boucher, Anne-Mieke Vandamme
发表日期
2013/12
期刊
Retrovirology
卷号
10
页码范围
1-13
出版商
BioMed Central
简介
Background
Understanding HIV-1 subtype distribution and epidemiology can assist preventive measures and clinical decisions. Sequence variation may affect antiviral drug resistance development, disease progression, evolutionary rates and transmission routes.
Results
We investigated the subtype distribution of HIV-1 in Europe and Israel in a representative sample of patients diagnosed between 2002 and 2005 and related it to the demographic data available. 2793 PRO-RT sequences were subtyped either with the REGA Subtyping tool or by a manual procedure that included phylogenetic tree and recombination analysis. The most prevalent subtypes/CRFs in our dataset were subtype B (66.1%), followed by sub-subtype A1 (6.9%), subtype C (6.8%) and CRF02_AG (4.7%). Substantial differences in the proportion of new diagnoses with distinct …
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AB Abecasis, AMJ Wensing, D Paraskevis… - Retrovirology, 2013