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Developing and excavating new agrochemicals with highly active and safe is an important tactic for protecting crop health and food safety. In this paper, to discover the new bactericide candidates, we designed, prepared a new type of 1,2,3,4-tetrahydro-β-carboline (THC) derivatives and evaluated the in vitro and in vivo bioactivities against the Xanthomonas oryzae pv. oryzae (Xoo), Xanthomonas axonopodis pv. citri (Xac), and Pseudomonas syringae pv. actinidiae (Psa). The in vitro bioassay results exhibited that most title molecules possessed good activity toward the three plant pathogenic bacteria, the compound A₁₇ showed the most active against Xoo and Xac with EC₅₀ values of 7.27 and 4.89 mg mL^–1 respectively, and compound A₈ exhibited the best inhibitory activity against Psa with EC₅₀ value of 4.87 mg mL^–1. Pot experiments showed that compound A₁₇ exhibited excellent in vivo antibacterial …