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Systemic sclerosis (SSc), an autoimmune disease with features including fibroblast transition and over-synthesis of extracellular matrix, yet has limited treatment options. Recent studies demonstrate that aberrant fibroblast activation is, at least in part, a consequence of mitochondrial dysfunction and associated metabolic reshaping. Sodium pyruvate, widely used as a nutritional supplement, is the stable form of pyruvate acid which acts as a central hub in several key metabolic pathways including glycolysis, the tricarboxylic acid (TCA) cycle and fatty acid metabolism.

In the current study, we tested the hypothesis that pyruvate supplementation may improve mitochondrial fitness to ameliorate the metabolic alterations in SSc, and that metabolic rebalancing may exert an anti-fibrotic therapeutic effect in a preclinical model of SSc.

The effect of sodium pyruvate on metabolism, mitochondrial …