作者
Gerard Sanacora, Graeme F Mason, Douglas L Rothman, Kevin L Behar, Fahmeed Hyder, Ognen AC Petroff, Robert M Berman, Dennis S Charney, John H Krystal
发表日期
1999/11/1
期刊
Archives of general psychiatry
卷号
56
期号
11
页码范围
1043-1047
出版商
American Medical Association
简介
Background
Several lines of emerging evidence suggest that dysfunction of γ-aminobutyric acid (GABA) systems is associated with major depression. However, investigation of this hypothesis is limited by difficulty obtaining noninvasive in vivo measures of brain GABA levels. In this study we used in vivo proton magnetic resonance spectroscopy to investigate the hypothesis that abnormalities in the GABA neurotransmitter system are associated with the neurobiologic processes of depression.
Methods
The GABA levels were measured in the occipital cortex of medication-free depressed patients meetingDSM-IVcriteria (n=14) and healthy control subjects with no history of mental illness (n=18) using a localized difference editing proton magnetic resonance spectroscopy protocol. An analysis of covariance was employed to examine the effects of depression, sex, and age.
Results
The depressed patients demonstrated a …
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