作者
Gerard Sanacora, Giulia Treccani, Maurizio Popoli
发表日期
2012/1/1
来源
Neuropharmacology
卷号
62
期号
1
页码范围
63-77
出版商
Pergamon
简介
Half a century after the first formulation of the monoamine hypothesis, compelling evidence implies that long-term changes in an array of brain areas and circuits mediating complex cognitive–emotional behaviors represent the biological underpinnings of mood/anxiety disorders. A large number of clinical studies suggest that pathophysiology is associated with dysfunction of the predominant glutamatergic system, malfunction in the mechanisms regulating clearance and metabolism of glutamate, and cytoarchitectural/morphological maladaptive changes in a number of brain areas mediating cognitive–emotional behaviors. Concurrently, a wealth of data from animal models have shown that different types of environmental stress enhance glutamate release/transmission in limbic/cortical areas and exert powerful structural effects, inducing dendritic remodeling, reduction of synapses and possibly volumetric reductions …
学术搜索中的文章
G Sanacora, G Treccani, M Popoli - Neuropharmacology, 2012