作者
Victor R Grann, Natalie Bowman, Cecil Joseph, Ying Wei, Marshall S Horwitz, Judith S Jacobson, Regina P Santella, Dawn L Hershman
发表日期
2008/8/15
期刊
Cancer: Interdisciplinary International Journal of the American Cancer Society
卷号
113
期号
4
页码范围
854-860
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
BACKGROUND
Low white blood cell counts (WBC) or absolute neutrophil counts (ANC) may delay or prevent the completion of appropriate chemotherapy, especially among women receiving adjuvant therapy for breast and colon cancer, and affect cancer survival. Because race/ethnicity is also associated with survival, the authors compared WBC and ANC in healthy American‐born women of African descent and European descent, and women from Barbados/Trinidad‐Tobago, the Dominican Republic, Haiti, and Jamaica.
METHODS
Blood samples from 261 healthy women ages 20 to 70 years were tested for WBC with differential, cytokine and growth factor levels, and ancestry informative and neutrophil elastase polymorphisms. The authors analyzed the association between neutropenia and serum WBC growth factor levels, cytokine levels, and neutrophil elastase c199a polymorphism.
RESULTS
The …
学术搜索中的文章
VR Grann, N Bowman, C Joseph, Y Wei, MS Horwitz… - Cancer: Interdisciplinary International Journal of the …, 2008