作者
Sarah B Joseph, Laura P Kincer, Natalie M Bowman, Chris Evans, Michael J Vinikoor, Christopher K Lippincott, Magnus Gisslén, Serena Spudich, Prema Menezes, Kevin Robertson, Nancie Archin, Angela Kashuba, Joseph J Eron, Richard W Price, Ronald Swanstrom
发表日期
2019/9/27
期刊
Clinical Infectious Diseases
卷号
69
期号
8
页码范围
1345-1352
出版商
Oxford University Press
简介
Background
Human immunodeficiency virus type 1 (HIV-1) populations are detected in cerebrospinal fluid (CSF) of some people on suppressive antiretroviral therapy (ART). Detailed analysis of these populations may reveal whether they are produced by central nervous system (CNS) reservoirs.
Methods
We performed a study of 101 asymptomatic participants on stable ART. HIV-1 RNA concentrations were cross-sectionally measured in CSF and plasma. In participants with CSF HIV-1 RNA concentrations sufficient for analysis, viral populations were genetically and phenotypically characterized over multiple time points.
Results
For 6% of participants (6 of 101), the concentration of HIV-1 RNA in their CSF was ≥0.5 log copies/mL above that of plasma (ie, CSF escape). We generated viral envelope sequences from CSF of 3 participants. One had a …
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SB Joseph, LP Kincer, NM Bowman, C Evans… - Clinical Infectious Diseases, 2019