作者
J Tyson McDonald, Francisco J Enguita, Deanne Taylor, Robert J Griffin, Waldemar Priebe, Mark R Emmett, Mohammad M Sajadi, Anthony D Harris, Jean Clement, Joseph M Dybas, Nukhet Aykin-Burns, Joseph W Guarnieri, Larry N Singh, Peter Grabham, Stephen B Baylin, Aliza Yousey, Andrea N Pearson, Peter M Corry, Amanda Saravia-Butler, Thomas R Aunins, Sadhana Sharma, Prashant Nagpal, Cem Meydan, Jonathan Foox, Christopher Mozsary, Bianca Cerqueira, Viktorija Zaksas, Urminder Singh, Eve Syrkin Wurtele, Sylvain V Costes, Gustavo Gastao Davanzo, Diego Galeano, Alberto Paccanaro, Suzanne L Meinig, Robert S Hagan, Natalie M Bowman, Shannon M Wallet, Robert Maile, Matthew C Wolfgang, Jason R Mock, Jose L Torres-Castillo, Miriya K Love, Will Lovell, Colleen Rice, Olivia Mitchem, Dominique Burgess, Jessica Suggs, Jordan Jacobs, Selin Altinok, Nicolae Sapoval, Todd J Treangen, Pedro M Moraes-Vieira, Charles Vanderburg, Douglas C Wallace, Jonathan C Schisler, Christopher E Mason, Anushree Chatterjee, Robert Meller, Afshin Beheshti
发表日期
2021/10/19
期刊
Cell reports
卷号
37
期号
3
出版商
Elsevier
简介
MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene regulation that have a major impact on many diseases and provide an exciting avenue toward antiviral therapeutics. From patient transcriptomic data, we determined that a circulating miRNA, miR-2392, is directly involved with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) machinery during host infection. Specifically, we show that miR-2392 is key in driving downstream suppression of mitochondrial gene expression, increasing inflammation, glycolysis, and hypoxia, as well as promoting many symptoms associated with coronavirus disease 2019 (COVID-19) infection. We demonstrate that miR-2392 is present in the blood and urine of patients positive for COVID-19 but is not present in patients negative for COVID-19. These findings indicate the potential for developing a minimally invasive COVID-19 detection …
学术搜索中的文章
JT McDonald, FJ Enguita, D Taylor, RJ Griffin, W Priebe… - Cell reports, 2021