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Materials and methods.

We performed a seroepidemiological survey (n= 210) of anti-HBs in 2011 in the central province of Iran, Semnan using enzyme-linked immunosorbent assay (ELISA). The levels of anti-HBs< 10 mIU/mL were considered to be negative and samples showing an anti-HBs titer≥ 10 mIU/mL was considered protective.

Results.

Protective antibody levels were detected in 88% of the children less than 5 year after vaccination, decreased to 78% between 5 to 10 years after vaccination, and further declined to 74% in 10 years after vaccination, respectively.

Conclusion.

The vaccination program has been proven effective in Semnan and immunological protection against hepatitis B infection was found in the majority of children even more than 10 years after being vaccinated.