查看文章

We demonstrate magnesium zinc oxide nanostructure (MZO nano) modified multifunctional devices for the full-scale dynamic monitoring of Pseudomonas aeruginosa (P. aeruginosa) biofilm formation: the dual-gate thin film transistor (DGTFT) as an electrical sensor for early stage detection and the quartz crystal microbalance (QCM) as an acoustic sensor for long-term monitoring. The sensing surfaces of both devices were modified with MZO nano to enhance their sensitivity and biocompatibility. P. aeruginosa bacteria were cultured in vitro on both sensing surfaces. The early stage detection is realized by sensing the charge transfer from cell membrane to the MZO nano during bacterial adhesion using the DGTFT biosensor while the monitoring of the long-term evolution is achieved through the sensing of mass loading and viscoelastic transition during biofilm development using the MZO nano QCM. The drain …