作者
Anjuli S Nayak, Guy A Settipane, Andrew Pedinoff, B Lauren Charous, Eli O Meltzer, William W Busse, S James Zinreich, Richard R Lorber, Ger Rikken, Melvyn R Danzig
发表日期
2002/9/1
期刊
Annals of Allergy, Asthma & Immunology
卷号
89
期号
3
页码范围
271-278
出版商
Elsevier
简介
BACKGROUND
Mometasone furoate nasal spray (MFNS) 400 μg, twice daily, as adjunctive treatment with oral antibiotic significantly improved symptoms of recurrent rhinosinusitis.
OBJECTIVE
To evaluate the effectiveness and safety of MFNS 200 μg, twice daily, and 400 μg, twice daily, compared with placebo as adjunctive treatment with oral antibiotic for acute rhinosinusitis.
METHODS
In this multicenter, double-blind, placebo-controlled study, 967 outpatients with computed tomographic scan-confirmed moderate to severe rhinosinusitis received amoxicillin/clavulanate potassium (Augmentin, GlaxoSmithKline, Research Triangle Park, NC) 875 mg, twice daily, for 21 days with adjunctive twice daily MFNS 200 μg, MFNS 400 μg, or placebo nasal spray. Patients recorded scores of six rhinosinusitis symptoms and any adverse events twice daily. Pre- and postcosyntropin–stimulation plasma cortisol levels were …
引用总数
学术搜索中的文章
AS Nayak, GA Settipane, A Pedinoff, BL Charous… - Annals of Allergy, Asthma & Immunology, 2002