作者
KP Economopoulos, NL Ward, CD Phillips, A Teshager, P Patel, MM Mohamed, S Hakimian, SB Cox, R Ahmed, O Moaven, K Kaliannan, SN Alam, JF Haller, AM Goldstein, AK Bhan, MS Malo, RA Hodin
发表日期
2016/5
期刊
Diabetes, Obesity and Metabolism
卷号
18
期号
5
页码范围
519-527
出版商
Blackwell Publishing Ltd
简介
Aims
To examine whether co‐administration of intestinal alkaline phosphatase (IAP) with antibiotics early in life may have a preventive role against metabolic syndrome (MetS) in mice.
Methods
A total of 50 mice were allocated to four treatment groups after weaning. Mice were treated with azithromycin (AZT) ± IAP, or with no AZT ± IAP, for three intermittent 7‐day cycles. After the last treatment course, the mice were administered a regular chow diet for 5 weeks and subsequently a high‐fat diet for 5 weeks. Body weight, food intake, water intake, serum lipids, glucose levels and liver lipids were compared. 16S rRNA gene pyrosequencing was used to determine the differences in microbiome composition.
Results
Exposure to AZT early in life rendered mice susceptible to MetS in adulthood. Co‐administration of IAP with AZT completely prevented this susceptibility by decreasing total body weight, serum lipids …
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KP Economopoulos, NL Ward, CD Phillips, A Teshager… - Diabetes, Obesity and Metabolism, 2016