作者
Michele Spinicci, Alessio Mazzoni, Marco Coppi, Alberto Antonelli, Lorenzo Salvati, Laura Maggi, Gregorio Basile, Lucia Graziani, Nicoletta Di Lauria, Vincenzo Di Pilato, Seble Tekle Kiros, Enrico Beccastrini, Riccardo Saccardi, Manuela Angileri, Michele Cecchi, Maria Grazia Cusi, Gian Maria Rossolini, Francesco Annunziato, Alessandro Bartoloni, Paola Parronchi
发表日期
2022/10
期刊
Journal of clinical immunology
卷号
42
期号
7
页码范围
1371-1378
出版商
Springer US
简介
Purpose
SARS-CoV-2 infection in immunocompromised hosts is challenging, and prolonged viral shedding can be a common complication in these patients. We describe the clinical, immunological, and virological course of a patient with eosinophilic granulomatosis with polyangiitis, who developed the status of long-term asymptomatic SARS-CoV-2 carrier for more than 7 months.
Methods
Over the study period, the patient underwent 20 RT-PCR tests for SARS-CoV-2 detection on nasopharyngeal swabs. In addition, viral cultures and genetic investigation of SARS-CoV-2 were performed. As for immunological assessment, serological and specific T-cell testing was provided at different time points.
Results
Despite the patient showing a deep drug-induced B and T adaptive immunity impairment, he did not experience COVID-19 progression to severe complications, and the infection remained asymptomatic during the …
学术搜索中的文章
M Spinicci, A Mazzoni, M Coppi, A Antonelli, L Salvati… - Journal of clinical immunology, 2022