作者
Marco Coppi, Alberto Antonelli, Claudia Niccolai, Andrea Bartolini, Laura Bartolini, Maddalena Grazzini, Elisabetta Mantengoli, Alberto Farese, Filippo Pieralli, Maria Teresa Mechi, Vincenzo Di Pilato, Tommaso Giani, Gian Maria Rossolini
发表日期
2022/10/27
期刊
Eurosurveillance
卷号
27
期号
43
页码范围
2200795
出版商
European Centre for Disease Prevention and Control
简介
A nosocomial outbreak by cefiderocol (FDC)-resistant NDM-1-producing Klebsiella pneumoniae (NDM-Kp) occurred in a large tertiary care hospital from August 2021–June 2022 in Florence, Italy, an area where NDM-Kp strains have become endemic. Retrospective analysis of NDM-Kp from cases observed in January 2021–June 2022 revealed that 21/52 were FDC-resistant. The outbreak was mostly sustained by clonal expansion of a mutant with inactivated cirA siderophore receptor gene, which exhibited high-level resistance to FDC (MIC ≥ 32 mg/L) and spread independently of FDC exposure.
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M Coppi, A Antonelli, C Niccolai, A Bartolini, L Bartolini… - Eurosurveillance, 2022