作者
C Tellapragada, B Hasan, A Antonelli, A Maruri, Corné de Vogel, D Gijón, M Coppi, A Verbon, Willem van Wamel, GM Rossolini, Rafael Cantón, Christian G Giske
发表日期
2020/10/1
期刊
Clinical Microbiology and Infection
卷号
26
期号
10
页码范围
1413. e1-1413. e7
出版商
Elsevier
简介
Objectives
To evaluate the performance of an isothermal microcalorimetry (IMC) method for determining the MICs among extensively drug-resistant Gram-negative bacilli.
Methods
A collection of 320 clinical isolates (n = 80 of each) of Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii from Sweden, Spain, Italy and the Netherlands were tested. The MICs were determined using the IMC device calScreener (Symcel, Stockholm, Sweden) and ISO-broth microdilution as the reference method. Essential agreement, categorical agreement, very major errors (VME), major errors (ME) and minor (mE) errors for each antibiotic were determined.
Results
Data from 316 isolates were evaluated. Four errors (two ME, one VME, one mE) among 80 K. pneumoniae, six errors (four ME, one VME, one mE) among 79 E. coli, 15 errors (seven VME, three ME, five mE) among 77 P. aeruginosa …
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