作者
FT Cutts, SMA Zaman, G ym Enwere, S Jaffar, OS Levine, JB Okoko, C Oluwalana, A Vaughan, SK Obaro, A Leach, KP McAdam, E Biney, M Saaka, U Onwuchekwa, F Yallop, NF Pierce, BM Greenwood, RA Adegbola
发表日期
2005/3/26
期刊
The Lancet
卷号
365
期号
9465
页码范围
1139-1146
出版商
Elsevier
简介
Background
Pneumonia is estimated to cause 2 million deaths every year in children. Streptococcus pneumoniae is the most important cause of severe pneumonia. We aimed to assess the efficacy of a nine-valent pneumococcal conjugate vaccine in children.
Methods
We undertook a randomised, placebo-controlled, double-blind trial in eastern Gambia. Children age 6–51 weeks were randomly allocated three doses of either pneumococcal conjugate vaccine (n=8718) or placebo (8719), with intervals of at least 25 days between doses. Our primary outcome was first episode of radiological pneumonia. Secondary endpoints were clinical or severe clinical pneumonia, invasive pneumococcal disease, and all-cause admissions. Analyses were per protocol and intention to treat.
Findings
529 children assigned vaccine and 568 allocated placebo were not included in the per-protocol analysis. Results of per-protocol and …
引用总数
学术搜索中的文章
FT Cutts, SMA Zaman, G Enwere, S Jaffar, OS Levine… - The Lancet, 2005