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Digitalization confronts organizations with huge challenges and opportunities. With all economic and societal sectors being affected by emerging technologies, the digital economy is highly volatile, uncertain, complex, and ambiguous. Against this backdrop, this book reports on best practices and lessons learned from organizations that succeeded in tackling the challenges and seizing the opportunities of the digital economy. It illustrates how 21 organizations leveraged their capabilities to create disruptive innovation, to develop digital business models, and to digitally transform themselves. These cases stem from various industries and countries, covering the many facets that digitalization may have.