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Advances in vehicle automation and communication can dramatically reduce the economic and comprehensive costs of US crashes. This report quantifies in detail the crash-related gains of various vehicle automation and connectivity features and anticipates their near-term and long-range impacts on car crashes in Texas. It also documents the best practices for the Texas Department of Transportation (TxDOT) and other agencies to most cost-effectively facilitate Texans’ adoption and use of top technologies. This study estimated the adoption of connected and autonomous vehicle (CAV) technologies over the long term through the use of two surveys. The study also reviewed CAVs’ impacts on safety, and estimated crash count and crash cost reductions via various CAV technologies. Finally, the report presents a benefit-cost (BC) analysis that identifies top design and system management strategies for departments of transportation to follow, in the transition to new technologies and travel choices. This work provides practical recommendations emphasizing safety to assist TxDOT in optimally planning for these new technologies using a holistic and qualitative approach.