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Antidepressants exhibit a large variation in efficacy in treated individuals, and increasing evidence suggests that individual genetics contribute to antidepressant treatment response. However, genome-wide association studies (GWAS) of antidepressant response are limited by insufficient sample sizes as well as variability in defining treatment-related phenotypes, and no robustly replicated genome-wide associations have been detected to date. In this study, we both conducted GWAS and GWAS meta-analyses, to increase statistical power to detect genomic loci associated with antidepressant response.

Utilizing questionnaire data of treatment efficacy, we conducted a GWAS on antidepressant response in the Estonian Biobank, separately for selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs). GWAS results were first meta-analyzed with SSRI response GWAS …