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Designing uplink systems which group users with adaptive interference mitigation techniques is the objective of this research. Reduction in error rates and improvement in the energy efficiency is expected with this approach in addition to spectral efficiency. This paper reports a study on interference mitigation and transmission designs for groups of users in the uplinks. New formulations for the interference mitigation are produced based on the minimum mean square error and successive interference cancellation approach. By reducing the interference, the energy efficiency can be maintained and improved although the number of users per group increases. The measured error rates of this approach with user grouping achieve gains between 1 to 3 dB against that of the existing approach. With reduced complexity, the proposed scheme should be viable for practical deployment.