作者
Anne Funke-Kaiser, Aki S Havulinna, Tanja Zeller, Sebastian Appelbaum, Pekka Jousilahti, Erkki Vartiainen, Stefan Blankenberg, Karsten Sydow, Veikko Salomaa
发表日期
2014/5/1
期刊
Annals of medicine
卷号
46
期号
3
页码范围
155-162
出版商
Taylor & Francis
简介
Introduction. To examine whether midregional pro-adrenomedullin (MR-proADM) plasma concentrations predict incident cardiovascular outcomes in the general population. Natriuretic peptides (N-terminal pro-brain natriuretic peptide (NT-proBNP), B-type natriuretic peptide (BNP), and midregional pro-atrial natriuretic peptide (MR-proANP)) were analyzed for comparison.
Material and methods. MR-proADM plasma concentrations and those of the natriuretic peptides were determined in 8444 individuals of the FINRISK 1997 cohort. Patients were followed for 14 years (median). Cox regression analyses, discrimination, and reclassification analyses adjusting for Framingham risk factors were performed to evaluate the additional benefit from MR-proADM.
Results. MR-proADM concentrations significantly predicted all-cause death (hazard ratio highest quintile versus lowest 1.18, 95% confidence interval 1.08–1.28 …
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