作者
Johannes Tobias Neumann, Stergios Tzikas, Anne Funke-Kaiser, Sandra Wilde, Sebastian Appelbaum, Till Keller, Francisco Ojeda-Echevarria, Tanja Zeller, Isabella Zwiener, Christoph R Sinning, Annika Jagodzinski, Renate B Schnabel, Karl J Lackner, Thomas Münzel, Stefan Blankenberg, Philipp S Wild, Karsten Sydow
发表日期
2013/6/1
期刊
Atherosclerosis
卷号
228
期号
2
页码范围
451-459
出版商
Elsevier
简介
AIMS AND BACKGROUND
Midregional proadrenomedullin (MR-proADM) is a protein, which exerts various effects on the cardiovascular system. Recent studies underscored its prognostic implications in patients with acute dyspnea and cardiovascular diseases. Therefore, we aimed to determine the distribution of MR-proADM in the general population and to reveal potential associations of MR-proADM with cardiovascular risk factors and measures of subclinical cardiovascular disease.
METHODS AND RESULTS
MR-proADM plasma concentrations were determined in individuals of the population-based cohort of the Gutenberg Health Study (N = 5000) using a commercially available fluoroimmunoassay. Individuals were enrolled between April 2007 and October 2008. Subclinical cardiovascular disease was assessed using echocardiographic and functional measures of myocardial and vascular function. The …
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JT Neumann, S Tzikas, A Funke-Kaiser, S Wilde… - Atherosclerosis, 2013