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For an Intelligent Decision Support System to work in real-time, it is of great value the use of intelligent agents that cooperate with each other to accomplish their tasks. In a critical environment like an Intensive Care Unit, doctors should have the right information, at the right time, to better assist their patients. In this paper we present an architecture for a Multi-Agents System that will support doctors’ decision by in realtime, guaranteeing that all required clinical data is available and capable of predicting the patients’ condition for the next hour.