作者
Tobias Keck, UF Wellner, M Bahra, F Klein, O Sick, M Niedergethmann, TJ Wilhelm, SA Farkas, T Börner, C Bruns, A Kleespies, J Kleeff, AL Mihaljevic, W Uhl, A Chromik, V Fendrich, K Heeger, W Padberg, A Hecker, UP Neumann, K Junge, JC Kalff, TR Glowka, J Werner, P Knebel, P Piso, M Mayr, J Izbicki, Y Vashist, P Bronsert, T Bruckner, R Limprecht, MK Diener, I Rossion, I Wegener, UT Hopt
发表日期
2016/3/1
来源
Annals of surgery
卷号
263
期号
3
页码范围
440-449
出版商
LWW
简介
Objectives:
To assess pancreatic fistula rate and secondary endpoints after pancreatogastrostomy (PG) versus pancreatojejunostomy (PJ) for reconstruction in pancreatoduodenectomy in the setting of a multicenter randomized controlled trial.
Background:
PJ and PG are established methods for reconstruction in pancreatoduodenectomy. Recent prospective trials suggest superiority of the PG regarding perioperative complications.
Methods:
A multicenter prospective randomized controlled trial comparing PG with PJ was conducted involving 14 German high-volume academic centers for pancreatic surgery. The primary endpoint was clinically relevant postoperative pancreatic fistula. Secondary endpoints comprised perioperative outcome and pancreatic function and quality of life measured at 6 and 12 months of follow-up.
Results:
From May 2011 to December 2012, 440 patients were randomized, and 320 were …
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