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Pancreatic ductal adenocarcinoma (PDAC) is characterized by aggressive biology and poor prognosis even after resection. Long‐term survival is very rare and cannot be reliably predicted. Experimental data suggest an important role of epithelial‐mesenchymal transition (EMT) in invasion and metastasis of PDAC. Tumor budding is regarded as the morphological correlate of local invasion and cancer cell dissemination. The aim of this study was to evaluate the biological and prognostic implications of EMT and tumor budding in PDAC of the pancreatic head.

Patients were identified from a prospectively maintained database, and baseline, operative, histopathological, and follow‐up data were extracted. Serial tissue slices stained for Pan‐Cytokeratin served for analysis of tumor budding, and E‐Cadherin, Beta‐Catenin, and Vimentin staining for analysis of EMT. Baseline, operative …