作者
Peter Bronsert, Ilona Kohler, Sylvia Timme, Selina Kiefer, Martin Werner, Oliver Schilling, Yogesh Vashist, Frank Makowiec, Thomas Brabletz, Ulrich T Hopt, Dirk Bausch, Birte Kulemann, Tobias Keck, Ulrich F Wellner
发表日期
2014/7/1
期刊
Surgery
卷号
156
期号
1
页码范围
97-108
出版商
Mosby
简介
Background
Pancreatic ductal adenocarcinoma (PDAC) is characterized by an aggressive biology and poor prognosis. Experimental evidence has suggested a role for the transcriptional repressor Zinc finger E-box binding homeobox 1 (ZEB1) in epithelial-mesenchymal transition, invasion, and metastasis in PDAC. ZEB1 expression has been observed in cancer cells as well as stromal fibroblasts. Our study aimed to evaluate the prognostic value of ZEB1 expression in PDAC tissue.
Methods
Patient baseline and follow-up data were extracted from a prospectively maintained database. After clinicopathologic re-review, serial sliced tissue slides were immunostained for ZEB1, E-cadherin, vimentin, and pan-cytokeratin. ZEB1 expression in cancer cells and adjacent stromal fibroblasts was graded separately and correlated to routine histopathologic parameters and survival after resection.
Results
A total of 117 cases of …
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P Bronsert, I Kohler, S Timme, S Kiefer, M Werner… - Surgery, 2014