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Purpose

To evaluate cortical and retinal activity by pattern visual evoked potentials (PVEP) in patients with type II diabetes mellitus.

Methods

PVEP was recorded in 40 diabetic patients including 20 subjects with non-proliferative diabetic retinopathy (NPDR) and 20 others without any retinopathy on fundus photography, and compared to 40 age-and sex-matched normal non-diabetic controls.

Results

P100 wave latency was significantly longer in diabetic patients as compared to normal controls (P< 0.001); both diabetic subjects without retinopathy and those with NPDR had significantly longer P100 latency than controls (P< 0.001 for both comparisons). There was significant reduction in N75 (P= 0.037) and P100 (P= 0.001) amplitudes in diabetic subjects. No correlation was observed between VEP amplitude or wave latency, and the level of glycemia or duration of diabetes mellitus.

Conclusion

Increased PVEP latency …