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The issue of chemical process optimization when at the operation stage the design specification should be met with some probability and the control variables can be changed has been considered. A common approach for solving the broad class of optimization problems with normally distributed uncertain parameters were developed. This class includes the one‐stage and two‐stage optimization problems with chance constraints. This approach is based on approximate transformation of chance constraints into deterministic ones. © 2013 American Institute of Chemical Engineers AIChE J, 59: 2471–2484, 2013