作者
Neda Eskandari, Mohammad Mahdi Nejadi Babadaei, Sanaz Nikpur, Ghazal Ghasrahmad, Farnoosh Attar, Masoumeh Heshmati, Keivan Akhtari, Seyed Mahdi Rezayat Sorkhabadi, Seyyedeh Elaheh Mousavi, Mojtaba Falahati
发表日期
2018/8/10
期刊
International journal of nanomedicine
页码范围
4575-4589
出版商
Taylor & Francis
简介
Introduction
The application of nanoparticles (NPs) in medicine and biology has received great interest due to their novel features. However, their adverse effects on the biological system are not well understood.
Materials and methods
This study aims to evaluate the effect of cerium oxide nanoparticles (CNPs) on conformational changes of human hemoglobin (HHb) and lymphocytes by different spectroscopic (intrinsic and synchronous fluorescence spectroscopy and far and near circular dichroism [CD] spectroscopy), docking and cellular (MTT and flow cytometry) investigations.
Results and discussion
Transmission electron microscopy (TEM) showed that CNP diameter is ~30 nm. The infrared spectrum demonstrated a strong band around 783 cm−1 corresponding to the CNP stretching bond. Fluorescence data revealed that the CNP is able to quench the intrinsic fluorescence of HHb through both dynamic and static …
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N Eskandari, MM Nejadi Babadaei, S Nikpur… - International journal of nanomedicine, 2018