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Hidradenitis suppurativa (HS) is characterized by recurrent abscesses and sinus tract formation leading to chronic non-healing wounds. We analyzed microarray gene expression of HS lesional and non-lesional skin samples (Blok et al., 2016). Differentially expressed genes (DEGs) in HS lesional vs. non-lesional skin were also compared to DEGs in punch-biopsy wounded vs. normal skin (Igelsias-Bertolome et al., 2018). A number of antimicrobial peptides and proteins (AMP), including members of the S100 family (log 2 FC= 4.85, p< 0.001), defensins (log 2 FC= 3.75, p< 0.001), and interferon stimulated antiviral genes, such as oligoadenylate synthetase 2 (log 2 FC= 1.88, p< 0.001), were significantly upregulated in both HS lesional skin and wounded skin. In contrast, the AMP dermcidin (DCD) was among the most down-regulated genes in HS lesional skin (log 2 FC=-4.90, p< 0.001), but was up-regulated in …