作者
Gillian K Gresham, George A Wells, Sharlene Gill, Christopher Cameron, Derek J Jonker
发表日期
2014/12
来源
BMC cancer
卷号
14
页码范围
1-13
出版商
BioMed Central
简介
Background
Advanced pancreatic cancer confers poor prognosis and treatment advancement has been slow. Recent randomized clinical trials (RCTs) have demonstrated survival benefits for combination therapy compared to gemcitabine alone. However, the comparative benefits and harms of available combination chemotherapy treatments are not clear. We therefore conducted a systematic review and Bayesian network meta-analysis to assess the comparative safety and efficacy of chemotherapy regimens for the treatment of advanced pancreatic cancer.
Methods
MEDLINE, PubMed, EMBASE, Cochrane Central Registry of Clinical trials and abstracts from major scientific meetings were searched for RCTs published from 2002 to 2013. Key outcomes were overall survival (OS), progression free survival (PFS), and safety including grade 3–4 febrile …
学术搜索中的文章
GK Gresham, GA Wells, S Gill, C Cameron, DJ Jonker - BMC cancer, 2014