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Social distancing practices have been widely recommended to curb the COVID-19 pandemic. However, despite the medical consensus, many citizens have resisted adhering to and/or supporting its implementation. While this resistance may stem from the non-negligible personal economic costs of implementing social distancing, we argue that it may also reside in more fundamental differences in normative principles and belief systems, as reflected by political orientation. In a study conducted in Brazil, we test the relative importance of these explanations by examining whether and how support for social distancing varies according to self-identified political orientation and personal economic vulnerability. Results show that while economic vulnerability does not influence support for social distancing, conservatives are systematically less supportive of these practices than liberals. Discrepancies in sensitivity to threats to the economic system help explain the phenomenon.