作者
Sangeeta Mehta, Lisa Burry, Deborah Cook, Dean Fergusson, Marilyn Steinberg, John Granton, Margaret Herridge, Niall Ferguson, John Devlin, Maged Tanios, Peter Dodek, Robert Fowler, Karen Burns, Michael Jacka, Kendiss Olafson, Yoanna Skrobik, Paul Hébert, Elham Sabri, Maureen Meade, SLEAP Investigators, Canadian Critical Care Trials Group
发表日期
2012/11/21
期刊
Jama
卷号
308
期号
19
页码范围
1985-1992
出版商
American Medical Association
简介
Context
Protocolized sedation and daily sedation interruption are 2 strategies to minimize sedation and reduce the duration of mechanical ventilation and intensive care unit (ICU) stay. We hypothesized that combining these strategies would augment the benefits.
Objective
To compare protocolized sedation with protocolized sedation plus daily sedation interruption in critically ill patients.
Design, Setting, and Patients
Randomized controlled trial of 430 critically ill, mechanically ventilated adults conducted in 16 tertiary care medical and surgical ICUs in Canada and the United States between January 2008 and July 2011.
Intervention
Continuous opioid and/or benzodiazepine infusions and random allocation to protocolized sedation (n = 209) (control) or to protocolized sedation plus daily sedation interruption (n = 214). Using validated scales, nurses titrated infusions to achieve light sedation. For patients receiving daily …
学术搜索中的文章
S Mehta, L Burry, D Cook, D Fergusson, M Steinberg… - Jama, 2012