作者
Sangeeta Mehta, Deborah Cook, John W Devlin, Yoanna Skrobik, Maureen Meade, Dean Fergusson, Margaret Herridge, Marilyn Steinberg, John Granton, Niall Ferguson, Maged Tanios, Peter Dodek, Robert Fowler, Karen Burns, Michael Jacka, Kendiss Olafson, Ranjeeta Mallick, Steven Reynolds, Sean Keenan, Lisa Burry, SLEAP Investigators, Canadian Critical Care Trials Group
发表日期
2015/3/1
期刊
Critical care medicine
卷号
43
期号
3
页码范围
557-566
出版商
LWW
简介
Objective:
Delirium is common during critical illness and associated with adverse outcomes. We compared characteristics and outcomes of delirious and nondelirious patients enrolled in a multicenter trial comparing protocolized sedation with protocolized sedation plus daily sedation interruption.
Design:
Randomized trial.
Setting:
Sixteen North American medical and surgical ICUs.
Patients:
Four hundred thirty critically ill, mechanically ventilated adults.
Interventions:
All patients had hourly titration of opioid and benzodiazepine infusions using a validated sedation scale. For patients in the interruption group, infusions were resumed, if indicated, at half of previous doses. Delirium screening occurred daily; positive screening was defined as an Intensive Care Delirium Screening Checklist score of 4 or more at any time.
Measurements and Main Results:
Delirium was diagnosed in 226 of 420 assessed patients (53.8%). Coma …
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S Mehta, D Cook, JW Devlin, Y Skrobik, M Meade… - Critical care medicine, 2015